NIH Library Bioinformatics Support Program is organizing a Genomatix training class for August 6–7. The free training will be held in the NIH Library Training Room, Building 10, from 9:30 a.m. to 4 p.m. over two days. Day 1 will be for formal training; on Day 2, the instructor will be available for consultation in the NIH Library Training Room and at Bioinformatics Workstation 3. Registration is required (use the link provided below).
Description: Genomatix® provides technologies and solutions that facilitate the detailed computational analysis of genomic data, with a strong emphasis on understanding the molecular mechanisms of eukaryotic gene regulation and expression. Advanced application areas include automated workflows for the analysis of next generation sequencing (NGS) data for the quick transformation of information (i.e., mapped data) into biological knowledge. In this training course, students will learn the fundamentals of Genomatix tools, databases, and annotation sources, then further apply this knowledge to the analysis of various NGS data types.
Abstract: Students will be introduced to the Genomatix Software Suite/Genomatix Genome Analyzer and will learn how to:
- Explore comprehensive genome annotation and use it as a basis for detailed promoter and transcription factor binding site analyses (morning);
- Perform next generation sequencing (NGS) workflows for ChIP-Seq, RNA-Seq; and
- Identify and characterize disease-associated regulatory SNPs in genome-wide association study (GWAS).
Benefits: Students will gain the following benefits.
- Gain experience in quickly finding the most relevant genomic information for any gene(s) or genomic region;
- Acquire the skills to carry out a detailed analysis of promoters and promoter sets;
- Learn how to quickly and efficiently analyze transcription factor binding site patterns in genomic DNA;
- Apply Genomatix NGS workflow for ChIP-Seq and RNA-Seq datasets, including:
- peak calling; o transcription factor binding site enrichment;
- motif detection;
- annotation of target genes;
- pathway analysis or ChIP-Seq target regions and differential gene expression analysis;
- pathway analysis;
- isoform detection and visualization with Transcriptome Viewer
- Learn how to identify potential regulatory SNPs in GWAS datasets, and carry out a detailed functional analysis of their biological function and impact.
This class will be taught by Genomatix research staff and is open to NIH staff. For more information on how to access the NIH Library’s license for Genomatix Genome Analyzer, please visit Bioinformatics Analysis Tools and Databases.
Class registration is no longer available.