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OmicCircos: Data Visualization for Data Integration, April 21

OmicCircos is a free tool used to generate high-quality circular plots for visualizing annotations and genomic variations, including mutation patterns, copy number variations (CNVs), expression patterns, and methylation patterns. Such data are routinely generated from microarray and next-generation sequencing data. OmicCircos can be used to explore the relationships between omics signatures and clinical features.

OmicCircos is developed at the Center for Biomedical Informatics & Information Technology (CBIIT), NCI, and is freely available through Bioconductor.

The free training will be held in the NIH Library Training Room, Building 10, from 9:30 a.m. to 4 p.m. Registration is required (use the link provided below). This training will give an introduction to OmicCircos, followed by a demonstration and hands-on session. There will be two sessions. The morning session will be devoted to the web version of OmicCircos and the afternoon session will be devoted to programming using R language.

Morning session: The hands-on exercise will use simulation data and The Cancer Genome Atlas (TCGA) data. Participants will have a chance to:

  • Get familiar with OmicCircos
  • Draw basic circular plots
  • Learn how to add tracks to the circular plot
  • Visualize TCGA gene expression, CNV, and fusion protein data
  • Make an integrated image view of gene expression, CNV, and fusion protein data
  • Plot relationship/association between clinical (phenotype) and omics features

Afternoon session: This session describes OmicCircos parameter settings and tuning to construct circular plots with desired biological features. Example data from human, mouse, and bacteria genome will be used to demonstrate functions for color selection, annotation, labeling, zoom, and integration of traditional plotting. Programming experience in R studio is required. Participants will learn:

  • Data format
  • Installation
  • Basic plot setting
  • Advance parameter tuning
  • Integration of R statistics and plotting

The class will be taught by NCI staff and is open to NIH and HHS staff. For more information about the class and to register, please go to http://nihlibrary.beta.libcal.com/event/2364388.

Registration is full at this time; however, you can register to get on the wait list. Wait list registrants who come to the class and sign in will be given any seats that are still open at 9.30 a.m., on a first-come, first-served basis.

Sign language interpreters and other reasonable accommodations can be provided. If you require such accommodations, please contact the NIH Library Information Desk at 301.496.1080 five business days in advance. For TDD users/callers, please call the above number through the Federal Relay Service at 1.800.877.8339.

The NIH Library in Building 10 serves the information needs of NIH staff and select Department of Health and Human Services (HHS) agencies. The NIH Library is part of the Office of Research Services (ORS) in the Office of the Director (OD).