The NIH Library Bioinformatics Support Program is offering the class MetaCore: Enabling Systems Biology Research through Pathway Analysis on September 20. This free training will be held in the NIH Library Training Room, Building 10, from 9:30 a.m. to 4:00 p.m.
MetaCore is a web-based curated knowledge database and software suite for pathway analysis of experimental data and gene lists. The scope of data types includes microarray and sequence-based gene expression, SNPs and CGH arrays, RNAi screens, gene variants, proteomics, metabolomics, Co-IP pull-out, and other custom interactions which can all be analyzed in tandem. It includes over a million interactions including over 700,000 compounds and their targets.
MetaCore is based on a proprietary, manually curated, database of human protein-protein, protein-DNA, and protein-compound interactions, and metabolic and signaling pathways for human, mouse, and rat, supported by proprietary ontologies and controlled vocabulary. The analytical package includes easy-to-use, intuitive tools for searching and data visualization, enabling the identification of the most relevant biological pathways, networks, and processes in a “virtual lab.”
The Genomic Analysis Tools (GAT) help users upload gene variant files, run genotype analysis, filter/annotate variants, and perform downstream analysis of their filtered variants.
Students will learn how to:
Knowledge mine for gene, protein, disease, and compound information with supporting journal references
Upload gene lists and expression data, and filter on ontologies or significance
Perform functional enrichment of their own data or quality-controlled, publicly available, data
Explore Canonical Pathway Maps to find a connection between a gene/protein/drug and a known signaling pathway
Build signaling networks to investigate the molecular neighborhood around a molecule
Use the Genomic Analysis Tools to upload, compare, and analyze gene variants
Simplify the generation and prioritization of experimental hypotheses following “omics” or NGS experiments
Assess and validate potential therapeutic targets and disease biomarkers
Learn about easy-to-use workflows and reports
This class will be taught by MetaCore research scientists and is open to NIH (and HHS) staff.
For more information on how to access the NIH Library license for MetaCore and GAT, go to https://nihlibrary.nih.gov/services/bioinformatics-support
Registration for this class is no longer available.
Sign language interpreters and other reasonable accommodations can be provided. If you require such accommodations, please contact the NIH Library Information Desk at 301.496.1080 five business days in advance. For TDD users/callers, please call the above number through the Federal Relay Service at 1.800.877.8339.
The NIH Library in Building 10 serves the information needs of NIH staff and select Department of Health and Human Services (HHS) agencies. The NIH Library is part of the Office of Research Services (ORS) in the Office of the Director (OD).